Roles and mechanisms of garlic and its extracts o atherosclerosis: A review

Roles and mechanisms of garlic and its extracts o atherosclerosis: A review

نقش ها و مکانیسم های سیر و عصاره های آن در آترواسکلروز: یک بررسی

The prevention and treatment of cardiovascular diseases (CVDs) have achieved
initial results, but the number of CVD patients will increase rapidly in the next
10 years. Atherosclerosis (AS) is a significant risk factor for CVDs. The impact of
lifestyle and daily diet varies considerably between different countries and
continents and has been shown to affect the development of various
diseases such as diabetes and CVDs.

Primary and secondary prevention using alternative supplements and methods to avoid or reduce the use of traditional pharmacological drugs have also become popular. One of the
reasons for this is that pharmacological drugs with lipid-lowering, and blood
pressure-lowering effects cause many side effects that may negatively impact
the quality of life.

Patients are now emphasizing reliance on lifestyle changes to reduce cardiovascular risks. Garlic is a medicinal and edible plant that has been used for a long time. In order to reveal garlic application in the prevention and treatment of AS, reviewing the latest domestic and international studies through searching databases.

The result shows that the antiatherogenic role of garlic is eximious. And the mechanisms are mainly related to hypolipidemic, antioxidant, antithrombotic, inhibiting angiogenesis, protecting endothelial cells, anti-inflammatory, anti-apoptotic, inhibiting vascular smooth muscle
proliferation, and regulating gut microbiota.

The main signaling pathways involve AMPK/TLRs, Keap1/Nrf2, PI3K/AKT, PPARγ/LXRα, GEF-H1/RhoA/Rac, etc. The antiatherogenic actions and molecular mechanism of garlic were
reviewed in this study to obtain a robust evidence basis for the clinical
application and mechanistic study and provide a theoretical basis for further
utilization of garlic.
#شرکت دانش بنیان داروسازی مهر و ماه

آرتریواسکلروز (به انگلیسی: Arteriosclerosis )، یک اصطلاح کلی برای ضخیم‌شدن و سفتی دیوارهٔ سرخ‌رگ است. بعبارت دیگر هنگامی‌که عروق و رگ‌ها حالت ارتجاعی خود را ازدست می‌دهند و گاهی قطر عروق تغییر می‌کند. این بیماری در شریان‌های متوسط و بزرگ ایجادمی‌شود.
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