1.Curcumin, inflammation, and neurological disorders: How are they linked?

1.Curcumin, inflammation, and neurological disorders: How are they linked?

Background: Despite the extensive research in recent years, the current treatment modalities for neurological disorders are suboptimal. Curcumin, a polyphenol found in the Curcuma genus, has been shown to mitigate the pathophysiology and clinical sequelae involved in neuroinflammation and neurodegenerative diseases.

Methods: We searched the PubMed database for relevant publications on curcumin and its uses in treating neurological diseases. We also reviewed relevant clinical trials which appeared on searching PubMed database using
‘Curcumin and clinical trials’.

Results: This review details the pleiotropic immunomodulatory functions and neuroprotective properties of curcumin, its derivatives, and formulations in various preclinical and clinical investigations. The effects of curcumin
on neurodegenerative diseases such as Alzheimer’s disease (AD), amyotrophic lateral sclerosis (ALS), brain tumors, epilepsy, Huntington’s disorder (HD), ischemia, Parkinson’s disease (PD), multiple sclerosis (MS), and traumatic brain injury (TBI) with a major focus on associated signaling pathways have been thoroughly discussed.

Conclusion: This review demonstrates curcumin can suppress spinal neuroinflammation by modulating diverse astroglia-mediated cascades, ensuring the treatment of neurological disorders.

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